39:{"drug_id":931054,"title":"Daclatasvir","ind":"FDA-Labeled Indications
Hepatitis C, chronic, Genotype 3, in combination with sofosbuvir
","adult":"

General Dosage Information
- Safety and efficacy in liver transplant patients or those with decompensated cirrhosis have not been established.
Hepatitis C, chronic, Genotype 3, in combination with sofosbuvir
- Daclatasvir 60 mg orally once daily in combination with sofosbuvir (400 mg orally once daily) for 12 weeks
- Optimum duration of therapy in patients with cirrhosis is not established.

","ped":"General Dosage Information

Safety and efficacy have not been established in pediatric patients.

","side":"Common

Gastrointestinal:Nausea (8%)
Neurologic:Headache (14%)
Other:Fatigue (14%)

","prgnancy":"Fetal risk cannot be ruled out. (TH)
","intermajer":"

Amiodarone (theoretical)
Apixaban (theoretical)
Boceprevir (theoretical)
Bosentan (theoretical)
Clarithromycin (theoretical)
Conivaptan (theoretical)
Dabigatran Etexilate (theoretical)
Dexamethasone (theoretical)
Digoxin (theoretical)
Efavirenz (theoretical)
Etravirine (theoretical)
Indinavir (theoretical)
Itraconazole (theoretical)
Ketoconazole (theoretical)
Lopinavir (theoretical)
Modafinil (theoretical)
Nafcillin (theoretical)
Nefazodone (theoretical)
Nelfinavir (theoretical)
Nilotinib (theoretical)
Posaconazole (theoretical)
Rifapentine (theoretical)
Ritonavir (theoretical)
Saquinavir (theoretical)
Simeprevir (theoretical)
Telaprevir (theoretical)
Telithromycin (theoretical)
Voriconazole (theoretical)

","clinical":"

Instruct patient to report symptoms of bradycardia.
Side effects may include fatigue, nausea, diarrhea, or headache.
Instruct patient to take a missed dose as soon as possible on the same day. If it is not the same day, skip the missed dose.

","admin":"Oral

Give with or without food.

","interminor":null,"contra":"

Carbamazepine (theoretical)
Fosphenytoin (theoretical)
Phenytoin (theoretical)
Rifampin (theoretical)
St John's Wort (theoretical)

","clas":"Antiviral","mode":"Daclatasvir is a nonstructural protein 5A (NS5A) inhibitor that interferes with the hepatitis C virus (HCV) replication complex via inhibition of viral RNA replication and virion assembly. Daclatasvir is highly selective for HCV.
"}

Augidacla (Daclatasvir - NAD 60mg) – Full Drug Info.

SCIENTIFIC NAME

INDICATIONS

CLASSIFICATION

MECHANISM OF ACTION

CLINICAL USE

ADULT DOSE

PEDIATRIC DOSE

ADMINISTRATION

CONTRAINDICATIONS

SIDE EFFECTS

PREGNANCY

MAJOR INTERACTIONS

MINOR INTERACTIONS