3a:{"drug_id":927821,"title":"Nitazoxanide","ind":"FDA-Labeled Indications

Cryptosporidiosis
Giardiasis

Non-FDA Labeled Indications

Clostridium difficile colitis
Cryptosporidiosis - HIV infection
Infection by Fasciola
Intestinal parasitism, General
Viral gastroenteritis due to Rotavirus

","adult":"

Cryptosporidiosis
- 500 mg (1 tablet or 25 mL suspension) ORALLY every 12 hr with food for 3 days
Giardiasis
- 500 mg (1 tablet or 25 mL suspension) ORALLY every 12 hr with food for 3 days

","ped":"

Cryptosporidiosis
- (age 1 to 3 yr) 100 mg (5 mL) ORALLY every 12 hr with food for 3 days
- (age 4 to 11 yr) 200 mg (10 mL) ORALLY every 12 hr with food for 3 days
- (age 12 yr and older) 500 mg (1 tablet or 25 mL suspension) ORALLY every 12 hr with food for 3 days
Giardiasis
- (age 1 to 3 yr) 100 mg (5 mL) ORALLY every 12 hr with food for 3 days
- (age 4 to 11 yr) 200 mg (10 mL) ORALLY every 12 hr with food for 3 days
- (age 12 yr and older) 500 mg (1 tablet or 25 mL suspension) ORALLY every 12 hr with food for 3 days

","side":"Common

Gastrointestinal:Abdominal pain (6.6% to 7.8%), Diarrhea (2.1% to 4.2%), Nausea (up to 3%), Vomiting (up to 1.1%)
Neurologic:Headache (1.1% to 3.1%)

","prgnancy":"B (FDA)
","intermajer":null,"clinical":"

This drug may cause abdominal pain, diarrhea, nausea, vomiting, or headache.
Patient should take drug with food.

","admin":"Oral

(tablets, suspension) take with food
(suspension) shake well before measuring each dose

","interminor":null,"contra":null,"clas":"Antiprotozoal","mode":"Systemic: The antiprotozoal activity is believed to be due to the interference with the pyruvate:ferredoxin oxireductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic energy metabolism. Studies have shown that the PFOR enzyme from Giardia lamblia directly reduces nitazoxanide by transfer of electrons in the absence of ferredoxin. The DNA-derived PFOR protein sequence of Cryptosporidium parvum appears to be similar to that of Giardia lamblia. Interference with the PFOR enzyme-dependent electron transfer reaction may not be the only pathway by which nitazoxanide exhibits antiprotozoal activity.
"}

Cryptonaz (Nitazoxanide - Powder for Oral Suspension 100mg/5ml) – Full Drug Info.

SCIENTIFIC NAME

INDICATIONS

CLASSIFICATION

MECHANISM OF ACTION

CLINICAL USE

ADULT DOSE

PEDIATRIC DOSE

ADMINISTRATION

CONTRAINDICATIONS

SIDE EFFECTS

PREGNANCY

MAJOR INTERACTIONS

MINOR INTERACTIONS