39:{"drug_id":923278,"title":"Azathioprine Sodium","ind":"FDA-Labeled Indications

Renal transplant rejection, Adjunct; Prophylaxis
Rheumatoid arthritis

","adult":"

Important Note
- Azathioprine has been designated an orphan product for use in the treatment of graft-versus-host disease.
Renal transplant rejection, Adjunct; Prophylaxis
- (initial) 3 to 5 mg/kg IV as a single daily dose starting at the time of transplant; less commonly, therapy is started 1 to 3 days prior to transplantation; IV therapy (as sodium salt) is typically administered initially, and then patients are switched to oral therapy (at the same dosage) after the postoperative period
- (maintenance) 1 to 3 mg/kg/day
Rheumatoid arthritis
- (initial) 1 mg/kg/day (50 to 100 mg) IV as single dose or divided twice daily; may titrate by 0.5 mg/kg/day after 6 to 8 wk and every 4 wk thereafter; MAX dose is 2.5 mg/kg/day
- (maintenance) may lower dose by 0.5 mg/kg/day every 4 wk (while keeping other drug therapy constant) until lowest effective dose is reached

","ped":"

Important Note
- Azathioprine has been designated an orphan product for use in the treatment of graft-versus-host disease.
General Dosage Information
- safety and efficacy not established in pediatric patients

","side":"$3a","prgnancy":"

Azathioprine: D (FDA)
Azathioprine: D (AUS)

","intermajer":"$3b","clinical":"

Advise patient of increased risk of malignancies and to report persistent fevers, night sweats, or significant weight loss.
This drug may cause myelosuppression and gastrointestinal toxicity.
Instruct patient to report any unusual bleeding or bruising.
Instruct patient to report signs/symptoms of infection.
Advise patient there are multiple significant drug-drug interactions for this drug. Consult healthcare professional prior to new drug use (including over-the-counter and herbal drugs).

","admin":"

General Information
- use proper procedures for handling and disposal of immunosuppressant agents
Intravenous
- for IV use only
- reconstitute vial with 10 mL Sterile Water for Injection (final vial dose of 100 mg); use within 24 hr
- may further dilute in sterile saline or dextrose; volume depends on infusion duration
- usual infusion time is 30 to 60 min (range, 5 min to 8 hr)

","interminor":"

Acenocoumarol (probable)
Cyclosporine (probable)
Phenprocoumon (probable)
Warfarin (probable)

","contra":"

Febuxostat (theoretical)","clas":"Antimetabolite","mode":"Azathioprine is an imidazolyl derivative of 6-mercaptopurine and acts as an immunosuppressive antimetabolite. The exact mechanism of immunosuppressive action is unknown because the exact mechanism of the immune response itself is complex and not completely understood. Azathioprine suppresses cell-mediated hypersensitivities and causes alterations in antibody production.
"}

Imuprin (Azathioprine - Tablet 50 mg) – Full Drug Info.

SCIENTIFIC NAME

INDICATIONS

CLASSIFICATION

MECHANISM OF ACTION

CLINICAL USE

ADULT DOSE

PEDIATRIC DOSE

ADMINISTRATION

CONTRAINDICATIONS

SIDE EFFECTS

PREGNANCY

MAJOR INTERACTIONS

MINOR INTERACTIONS