3a:{"drug_id":924640,"title":"Montelukast Sodium","ind":"FDA-Labeled Indications

Asthma; Treatment and Prophylaxis
Exercise-induced asthma; Prophylaxis
Perennial allergic rhinitis
Seasonal allergic rhinitis

Non-FDA Labeled Indications

Acute bronchiolitis due to respiratory syncytial virus
Aspirin-induced asthma
Atopic dermatitis
Obstructive sleep apnea, Nonsevere
Seasonal allergic conjunctivitis
Urticaria, chronic, Refractory; Adjunct

","adult":"

Asthma; Treatment and Prophylaxis
- 10 mg orally in the evening
Exercise-induced asthma; Prophylaxis
- 10 mg ORALLY as a single dose at least 2 hours before exercise, no additional doses should be taken within 24 hours of previous dose
Perennial allergic rhinitis
- 10 mg ORALLY once daily in the evening
Seasonal allergic rhinitis
- 10 mg ORALLY in the evening

","ped":"$3b","side":"Common
Neurologic:Headache (adult and adolescent; 18.4%; pediatric, 2% or greater)
Serious

Cardiovascular:Allergic granulomatosis angiitis
Immunologic:Stevens-Johnson syndrome, Toxic epidermal necrolysis
Psychiatric:Aggressive behavior, Altered behavior, Suicidal thoughts
Renal:Hematuria

","prgnancy":"

Montelukast: B (FDA)
Montelukast: B1 (AUS)

","intermajer":"

Clozapine (theoretical)
Cobicistat (theoretical)
Dasabuvir (theoretical)
Nilotinib (theoretical)
Pixantrone (theoretical)

","clinical":"

Advise patient that this drug is not indicated for acute asthma attacks.
This drug may cause aggressive behavior, agitation, dream disorder, or hallucinations.
Instruct patient to report increased use or frequency of short-acting inhaled bronchodilators.
Patients with asthma should take dose in the evening.
Advise patient not to discontinue or decrease the dose of other asthma medications unless instructed by a healthcare professional.

","admin":"Oral

patients with both asthma and allergic rhinitis should take the daily dose in the evening
(granules) can be administered either directly in mouth, dissolved in 5 mL of cold or room-temperature baby formula or breast milk, or mixed with a spoonful of cold or room-temperature food (applesauce, carrots, rice, or ice cream only)
(granules) dose must be administered within 15 minutes of opening packet; discard unused portion

","interminor":"

Gemfibrozil (established)
Prednisone (probable)

","contra":null,"clas":"Anti-Inflammatory","mode":"Montelukast sodium is a selective and active leukotriene receptor antagonist. It binds to cysteinyl leukotrienes (CysLT) type-1 receptors found in human airway (smooth muscle cells and macrophages), which prevents airway edema, smooth muscle contraction and other respiratory inflammation. The leukotrienes are also released from the nasal mucosa after allergen exposure where montelukast sodium may inhibit symptoms of allergic rhinitis.
"}

Montolair (Montelukast Sodium - NAD 10 mg) – Full Drug Info.

SCIENTIFIC NAME

INDICATIONS

CLASSIFICATION

MECHANISM OF ACTION

CLINICAL USE

ADULT DOSE

PEDIATRIC DOSE

ADMINISTRATION

CONTRAINDICATIONS

SIDE EFFECTS

PREGNANCY

MAJOR INTERACTIONS

MINOR INTERACTIONS