39:{"drug_id":928760,"title":"Aliskiren","ind":"FDA-Labeled Indications
Hypertension
Non-FDA Labeled Indications

Diabetic nephropathy - Hypertension
Renal impairment, chronic, Nondiabetic

","adult":"

Hypertension
- initial, 150 mg ORALLY once daily; may increase to 300 mg/day based on clinical response
Renal impairment, chronic, Nondiabetic
- 150 mg ORALLY once daily

","ped":"General Dosage Information

safety and efficacy not established in pediatric patients

","side":"Common

Gastrointestinal:Diarrhea (2.3%)
Musculoskeletal:Musculoskeletal symptom
Neurologic:Dizziness, Headache (2.4% to 6.2%)
Renal:Serum blood urea nitrogen raised, Serum creatinine raised

Serious

Cardiovascular:Hypotension
Endocrine metabolic:Hyperkalemia (0.9%)
Immunologic:Anaphylaxis, Hypersensitivity reaction
Musculoskeletal:Increased creatine kinase level (1%)
Neurologic:Seizure
Renal:Renal impairment
Other:Angioedema (0.06%)

","prgnancy":"

D (FDA)
D (AUS)

","intermajer":"

Cyclosporine (probable)
Eliglustat (theoretical)
Itraconazole (probable)
Lomitapide (theoretical)
Nilotinib (theoretical)
Simeprevir (theoretical)
Tocophersolan (theoretical)
Ulipristal (theoretical)

","clinical":"

This drug may cause angioedema of the face, extremities, lips, tongue, glottis, and/or larynx. Advise patient to report any signs of angioedema, including difficulty in breathing or swallowing.
This drug may cause persistent cough, diarrhea, or rash.
Patient should watch for signs/symptoms of hypotension with initial dose and dose changes. Advise patient to lie down if feeling faint or dizzy, and to rise slowly from a sitting/supine position.

","admin":"Oral

take consistently with regard to meals; high-fat meals reduce absorption significantly

","interminor":"

Furosemide (probable)
Rifampin (probable)

","contra":"

Azilsartan (probable)
Azilsartan Medoxomil (probable)
Benazepril (probable)
Candesartan (probable)
Captopril (probable)
Enalapril (probable)
Enalaprilat (probable)
Eprosartan (probable)
Fosinopril (probable)
Irbesartan (probable)
Lisinopril (probable)
Losartan (probable)
Moexipril (probable)
Olmesartan Medoxomil (probable)
Perindopril (probable)
Quinapril (probable)
Ramipril (probable)
Telmisartan (probable)
Trandolapril (probable)
Valsartan (probable)

","clas":"Antihypertensive","mode":"Aliskiren directly inhibits renin which decreases plasma renin activity (PRA) and inhibits the conversion of angiotensinogen to angiotensin I (Ang I). Unlike angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) which indirectly increase levels of PRA, aliskiren reduces PRA, Ang I, and Angiotensin II (Ang II) by directly inhibiting renin. These reductions occur whether or not aliskiren is used as monotherapy or concomitantly with other antihypertensive agents. It is unknown if aliskiren has an effect on other renin-angiotensin-aldosterone system (RAAS) components.
"}

Rasilez (Aliskiren - Tablet 150 mg) – Full Drug Info.

SCIENTIFIC NAME

INDICATIONS

CLASSIFICATION

MECHANISM OF ACTION

CLINICAL USE

ADULT DOSE

PEDIATRIC DOSE

ADMINISTRATION

CONTRAINDICATIONS

SIDE EFFECTS

PREGNANCY

MAJOR INTERACTIONS

MINOR INTERACTIONS