39:{"drug_id":923352,"title":"Tinidazole","ind":"FDA-Labeled Indications

Amebic liver abscess - Infection due to Entamoeba histolytica
Bacterial vaginosis
Infection by Giardia lamblia
Infection due to Entamoeba histolytica - Intestinal infectious disease
Trichomoniasis

Non-FDA Labeled Indications

Helicobacter pylori gastrointestinal tract infection
Nongonococcal urethritis

","adult":"

Amebic liver abscess - Infection due to Entamoeba histolytica
- 2 g ORALLY every day for 3 to 5 days
Bacterial vaginosis
- (nonpregnant women) 2 g ORALLY once daily for 2 days, OR 1 g ORALLY once daily for 5 days
Infection by Giardia lamblia
- 2 g ORALLY as a single dose
Infection due to Entamoeba histolytica - Intestinal infectious disease
- 2 g ORALLY every day for 3 days
Nongonococcal urethritis
- (recurrent or persistent) 2 g ORALLY in a single dose plus azithromycin 1 g orally in a single dose (if not used for initial episode)
Trichomoniasis
- 2 g ORALLY as a single dose; sexual partners should be treated with the same dose and at the same time

","ped":"

General Dosage Information
- safety and effectiveness in pediatric patients not established except for the treatment of giardiasis and amebiasis in patients older than 3 years
Amebic liver abscess - Infection due to Entamoeba histolytica
- 50 mg/kg/day (up to 2 g a day) ORALLY for 3 to 5 days
Infection by Giardia lamblia
- 50 mg/kg ORALLY (up to 2 g) as a single dose
Infection due to Entamoeba histolytica - Intestinal infectious disease
- 50 mg/kg every day (up to 2 g a day) ORALLY for 3 days

","side":"Common

Gastrointestinal:Nausea (3.2% to 4.5%), Taste sense altered (3.7% to 6.3%)
Reproductive:Candida vaginitis (4.7%)

Serious

Immunologic:Hypersensitivity reaction
Neurologic:Numbness, Paresthesia, Peripheral neuropathy, Seizure

","prgnancy":"

C (FDA)
B3 (AUS)

","intermajer":"

Capecitabine (theoretical)
Disulfiram (theoretical)
Doxifluridine (theoretical)
Fluorouracil (theoretical)
Tegafur (theoretical)

","clinical":"$3a","admin":"Oral

take with food to minimize epigastric discomfort and other gastrointestinal adverse effects
tablets may be crushed and mixed in artificial cherry syrup
avoid alcoholic beverages during and for 3 days after therapy completed

","interminor":null,"contra":null,"clas":"Antibiotic","mode":"Tinidazole, a synthetic antiprotozoal agent, possesses activity against Trichomonas through reduction of the nitro group by the organism. The free nitro radical produced is responsible for antiprotozoal activity. The mechanism against Giardia and Entamoeba is unknown and tinidazole does not possess activity against most lactobacilli strains in the vagina.
"}

Tinirem (Tinidazole - Tablet 500 mg) – Full Drug Info.

SCIENTIFIC NAME

INDICATIONS

CLASSIFICATION

MECHANISM OF ACTION

CLINICAL USE

ADULT DOSE

PEDIATRIC DOSE

ADMINISTRATION

CONTRAINDICATIONS

SIDE EFFECTS

PREGNANCY

MAJOR INTERACTIONS

MINOR INTERACTIONS