39:{"drug_id":339435,"title":"Lidocaine","ind":"FDA-Labeled Indications

Local anesthesia, Topical
Postherpetic neuralgia

Non-FDA Labeled Indications

Burn
Diabetic neuropathy
Hiccoughs, Intractable

","adult":"

Important Note
- Lidocaine patch 5% has been designated an orphan product for use in treatment of postherpetic pain following herpes zoster infection.
Hiccoughs, Intractable
- 5 mL of 2% viscous lidocaine solution ORALLY up to 4 times per day was used in 4 cases
Local anesthesia, Topical
- (5% ointment) single TOPICAL application not exceeding 5 g of ointment (containing 250 mg of lidocaine base); roughly equivalent to a 6 inch length of ointment from the tube; MAX dose of 17 to 20 g of ointment (850 to 1000 mg lidocaine base) per day
Postherpetic neuralgia
- Apply up to 3 patches (MAX) TOPICALLY only once, for up to 12 hours within a 24-hour period.

","ped":"

Important Note
- Lidocaine patch 5% has been designated an orphan product for use in treatment of postherpetic pain following herpes zoster infection.
Local anesthesia, Topical
- (5% ointment) MAX dose of 4.5 mg/kg TOPICALLY

","side":"Common

Cardiovascular:Hypotension (3%)
Gastrointestinal:Nausea (less than 1%)

Serious

Cardiovascular:Cardiac arrest, Cardiac dysrhythmia
Hematologic:Methemoglobinemia
Immunologic:Anaphylaxis (rare)

","prgnancy":"B (FDA)
","intermajer":"$3a","clinical":"

Instruct patient to take extra care to avoid injury of body areas that are numbed by lidocaine. Patient should avoid scratching, rubbing, or applying extreme temperatures until body area sensation returns.
Large amounts of topical preparations may increase risk of lidocaine toxicity.
This drug may cause skin irritation.
Instruct patients to report signs/symptoms of lidocaine toxicity, seizures, difficulty breathing, coma, or cardiac dysrhythmia
Advise patient not to apply topical preparations to broken or irritated skin.
Advise patient to use topical preparations sparingly.
Warn patients using topical preparations that occlusion of the skin with any type of material can increase the chance of serious side effects, as can applying heat.

","admin":"Topical

(Patch) Apply only to intact skin and remove patch after a maximum of 12 hours of application within a 24-hour period.
(Patch) May be cut into smaller sizes prior to removal of release liner
(Patch) Apply immediately after removal from protective envelope.
(Patch) Clothing may be worn over area of application.
(Patch) If irritation or burning occurs at the application site, remove the patch(es) and do not reapply until the irritation subsides.
(Patch) May not stick if wet; avoid contact with water (bathing, swimming, or showering)
(Patch) Wash hands after applying and avoid contact with eyes.
(Patch) Fold used patches so that adhesive side sticks to itself and safely discard.

","interminor":"

Cimetidine (probable)
Dalfopristin (probable)
Morphine Sulfate Liposome (established)
Penbutolol (probable)
Quinupristin (probable)

","contra":"

Dihydroergotamine (theoretical)
Dronedarone (theoretical)
Saquinavir (theoretical)

","clas":"Amino Amide","mode":"Lidocaine blocks both initiation and conduction of nerve impulses by decreasing ionic flux through the neuronal membrane, which results in local anesthesia after topical application. The penetration of lidocaine through intact skin will produce an analgesic effect but is not sufficient to produce complete sensory block.
"}

Xylocaine (Lidocaine - Solution 2%) – Full Drug Info.

SCIENTIFIC NAME

INDICATIONS

CLASSIFICATION

MECHANISM OF ACTION

CLINICAL USE

ADULT DOSE

PEDIATRIC DOSE

ADMINISTRATION

CONTRAINDICATIONS

SIDE EFFECTS

PREGNANCY

MAJOR INTERACTIONS

MINOR INTERACTIONS