3b:{"drug_id":623615,"title":"Tretinoin","ind":"FDA-Labeled Indications

Acne vulgaris
Acute promyelocytic leukemia, FAB M3, Induction therapy in patients who are refractory to, have relapsed from, or are not candidates for anthracycline chemotherapy
Fine wrinkles on face, With comprehensive skin care and sunlight avoidance programs; Adjunct
Hyperpigmentation of skin, Facial mottling; with comprehensive skin care and sunlight avoidance programs; Adjunct
Roughness of skin, Facial tactile roughness; with comprehensive skin care and sunlight avoidance programs; Adjunct

Non-FDA Labeled Indications

","adult":"$3c","ped":"

General Dosage Information
- (oral) safety and effectiveness not established in pediatric patients younger than 1 year
- (Renova(R)) safety and efficacy not established in pediatric patients
- (gel microsphere (Retin-A Micro(R))) safety and efficacy not established in pediatric patients younger than 12 years
Acne vulgaris
- (12 years or older) apply gel microsphere (0.1%, 0.04%) TOPICALLY to acne lesions once daily at bedtime
Acute promyelocytic leukemia, FAB M3, Induction therapy in patients who are refractory to, have relapsed from, or are not candidates for anthracycline chemotherapy
- 1 year or older, 45 mg/m(2)/day ORALLY (divided evenly twice daily) for 90 days or 30 days past complete remission whichever comes first

","side":"$3d","prgnancy":"

","intermajer":"

","clinical":"$3e","admin":"

Instillation, nasogastric tube
- all-trans retinoic acid was successfully administered to a ventilated patient via instillation of an extemporaneously compounded emulsion of the contents of all-trans retinoic acid capsules in soybean oil through an NG tube.
Sublingual
- all-trans retinoic acid was successfully administered to a comatose patient by squeezing the contents of the capsule onto the floor of the patient's mouth underneath the tongue
Topical
- wash face with mild soap, pat dry, and wait 20 to 30 minutes prior to application
- apply lightly to affected area before bedtime to clean skin avoiding eyes, ears, nostrils and mouth
- (gel and cream) may use fingertip to apply
- (liquid) may use fingertip, gauze pad or cotton swab to apply; do not oversaturate gauze pad or cotton swab so liquid does not run to areas where treatment is not intended

","interminor":"

","contra":null,"clas":"Antiacne","mode":"

Systemic: The precise mechanism of action has not been established. Tretinoin is not a cytolytic agent. It induces cytodifferentiation and decreases proliferation of acute promyelocytic leukemia cells. In patients who achieve complete remission, tretinoin therapy results in an initial maturation of the primitive promyelocytes derived from the leukemic clone, followed by a repopulation of the bone marrow and peripheral blood with normal, polyclonal hematopoietic cells.
Topical: The exact mechanism of tretinoin, a hormone and vitamin A analog, is not known. One possible explanation is altered gene expression causing changes in protein synthesis. .

Retin -A (Tretinoin - Cream 0.05%) – Full Drug Info.